Lung transplantation may be an option in severe cases. Medications specifically used to treat pulmonary hypertension include epoprostenol, treprostinil, iloprost, bosentan, ambrisentan, macitentan, and sildenafil, tadalafil, selexipag, riociguat. A number of supportive measures such as oxygen therapy, diuretics, and medications to inhibit blood clotting may be used. Treatment depends on the type of disease. Īs of 2022 there was no cure for pulmonary hypertension, although research to find a cure is ongoing. Diagnosis involves first ruling out other potential causes. The underlying mechanism typically involves inflammation and subsequent remodeling of the arteries in the lungs. Risk factors include a family history, prior pulmonary embolism (blood clots in the lungs), HIV/AIDS, sickle cell disease, cocaine use, chronic obstructive pulmonary disease, sleep apnea, living at high altitudes, and problems with the mitral valve. Īccording to the definition at the 6th World Symposium of Pulmonary Hypertension in 2018, a patient is deemed to have pulmonary hypertension if the pulmonary mean arterial pressure is greater than 20mmHg at rest, revised down from a purely arbitrary 25mmHg, and pulmonary vascular resistance (PVR) greater than 3 Wood units. The condition may make it difficult to exercise. Symptoms include shortness of breath, fainting, tiredness, chest pain, swelling of the legs, and a fast heartbeat. Pulmonary hypertension ( PH or PHTN) is a condition of increased blood pressure in the arteries of the lungs. Supportive care, various medications, lung transplantation Įpoprostenol, treprostinil, iloprost, bosentan, ambrisentan, macitentan, sildenafil Pulmonary arterial hypertension, Ayerza syndrome įamily history, pulmonary embolism, HIV/AIDS, sickle cell disease, cocaine use, COPD, sleep apnea, living at high altitudes įollowing ruling out other potential causes
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